Ras-interacting protein 1

RASIP1
Identifiers
Aliases	RASIP1, RAIN, Ras interacting protein 1
External IDs	OMIM: 609623 MGI: 1917153 HomoloGene: 9847 GeneCards: RASIP1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,740,610 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,288,517 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; spleen; ; subcutaneous adipose tissue; ; lower lobe of lung; ; left uterine tube; ; left ventricle; ; body of pancreas; ; body of stomach; ; right lobe of thyroid gland;
	Top expressed in
	vascular endothelium; ; interventricular septum; ; right lung; ; left lung; ; left lung lobe; ; capillary; ; right lung lobe; ; extensor digitorum longus muscle; ; plantaris muscle; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein homodimerization activity; GTPase binding;
Cellular component	perinuclear region of cytoplasm; cytoplasm; Golgi stack; Golgi apparatus; cell-cell junction; protein-containing complex;
Biological process	vasculogenesis; regulation of GTPase activity; negative regulation of autophagy; branching morphogenesis of an epithelial tube; angiogenesis; signal transduction; positive regulation of integrin activation; negative regulation of Rho protein signal transduction; negative regulation of membrane permeability; negative regulation of Rho-dependent protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	54922
	69903
	ENSG00000105538
	ENSMUSG00000044562
	Q5U651
	Q3U0S6
	NM_017805
	NM_028544; NM_027253
	NP_060275
	NP_082820
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-interacting protein 1 (Rain), is a protein that in humans is encoded by the RASIP1 gene.^[5]

Function

It is required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis.^[6]
Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis.^[7]^[8]^[9]
Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells.^[10]^[11]

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in RASIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how RASIP1 mutation contributes to disease.^[12]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105538 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044562 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein". www.uniprot.org. Retrieved 2021-12-11. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
↑ Wilson CW, Ye W (2014). "Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling". Cell Adhesion & Migration. 8 (2): 76–83. doi:10.4161/cam.28115. PMC 4049864. PMID 24622510.
↑ Koo Y, Barry DM, Xu K, Tanigaki K, Davis GE, Mineo C, Cleaver O (April 2016). "Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth". Angiogenesis. 19 (2): 173–190. doi:10.1007/s10456-016-9498-5. PMC 4808411. PMID 26897025.
↑ Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, et al. (August 2018). "Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions". Development. 145 (17): dev165092. doi:10.1242/dev.165092. PMC 6141773. PMID 30042182.
↑ Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O (May 2009). "Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation". Developmental Biology. 329 (2): 269–279. doi:10.1016/j.ydbio.2009.02.033. PMC 2683470. PMID 19272373.
↑ Barry DM, Koo Y, Norden PR, Wylie LA, Xu K, Wichaidit C, et al. (September 2016). "Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II". Circulation Research. 119 (7): 810–826. doi:10.1161/CIRCRESAHA.116.309094. PMC 5026621. PMID 27486147.
↑ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry. 279 (21): 22353–22361. doi:10.1074/jbc.M312867200. PMID 15031288.
↑ Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. PMID 34493870. S2CID 237442349.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105538 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044562 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein". www.uniprot.org. Retrieved 2021-12-11. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.

[6] Wilson CW, Ye W (2014). "Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling". Cell Adhesion & Migration. 8 (2): 76–83. doi:10.4161/cam.28115. PMC 4049864. PMID 24622510.

[7] Koo Y, Barry DM, Xu K, Tanigaki K, Davis GE, Mineo C, Cleaver O (April 2016). "Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth". Angiogenesis. 19 (2): 173–190. doi:10.1007/s10456-016-9498-5. PMC 4808411. PMID 26897025.

[8] Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, et al. (August 2018). "Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions". Development. 145 (17): dev165092. doi:10.1242/dev.165092. PMC 6141773. PMID 30042182.

[9] Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O (May 2009). "Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation". Developmental Biology. 329 (2): 269–279. doi:10.1016/j.ydbio.2009.02.033. PMC 2683470. PMID 19272373.

[10] Barry DM, Koo Y, Norden PR, Wylie LA, Xu K, Wichaidit C, et al. (September 2016). "Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II". Circulation Research. 119 (7): 810–826. doi:10.1161/CIRCRESAHA.116.309094. PMC 5026621. PMID 27486147.

[11] Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry. 279 (21): 22353–22361. doi:10.1074/jbc.M312867200. PMID 15031288.

[12] Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. PMID 34493870. S2CID 237442349.

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