San Domenico di Guzman may refer to :
- the Italian for Saint Dominic of Guzman
- Italian churches dedicated to him, notably
- San Domenico di Guzman (Rome), a cardinal-deaconry and Roman parish church
- Basilica of San Domenico, in Bologna
- San Domenico di Guzman (oratorio) an oratorio by Antonio Braga based on the saint's life
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