Speziale may refer to:
People
- Charles Speziale (1948 – 1999), American Aerospace engineer
- Jerry Speziale (born c. 1959), American law enforcement officer
- John A. Speziale (1922–2005), justice of the Connecticut Supreme Court
- Marie Speziale (born c. 1945), American musician
Artistic works
- Lo speziale, an opera buffa by Joseph Haydn
Places
- Speziale, a village in Italy
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