Singles
2021 Open Ciudad de Valencia
Champion	Arantxa Rus
Runner-up	Mihaela Buzărnescu
Score	6–4, 7–6(7–3)

Varvara Gracheva was the defending champion^[1] but chose to participate at the 2021 J&T Banka Ostrava Open instead.

Arantxa Rus won the title, defeating Mihaela Buzărnescu in the final, 6–4, 7–6^(7–3).

Seeds

Draw

Finals

	Semifinals							Final
	1	Arantxa Rus	77	6
		Seone Mendez	63	2
								1	Arantxa Rus	6	77
									Mihaela Buzărnescu	4	63
		Mihaela Buzărnescu	6	6
	9	Aliona Bolsova	4	2

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	A Rus	6	6
	Q	IG Ghioroaie	3	1				1	A Rus	6	6
		V Cepede Royg	3	77	2			Q	I Shymanovich	3	4
	Q	I Shymanovich	6	64	6										1	A Rus	6	6
	WC	Á Fita Boluda	6	6												D Seguel	4	1
	WC	R Masarova	1	3				WC	Á Fita Boluda	4	77	1
		D Seguel	6	64	6				D Seguel	6	61	6
	7	E Gorgodze	4	77	2																	1	A Rus	77	6
	4	I Bara	6	6																			S Mendez	63	2
	LL	A Carreras	4	3				4	I Bara	4	6	6
		C Paquet	6	77					C Paquet	6	4	4
		I Burillo Escorihuela	1	65											4	I Bara	3	710	4
		S Mendez	6	6												S Mendez	6	68	6
		S Waltert	3	0					S Mendez	6	6
	Q	L Romero Gormaz	3					Q	L Romero Gormaz	0	2
	6	D Gálfi	1r

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	K Kučová	77	3	3
	Q	A Prisăcariu	64	6	6			Q	A Prisăcariu	0	1
		P Ormaechea	3	63					M Buzărnescu	6	6
		M Buzărnescu	6	77												M Buzărnescu	6	6
	WC	A Gámiz	4	711	77										WC	A Gámiz	2	3
	Q	M Bassols Ribera	6	69	64			WC	A Gámiz	7	7
	WC	J Bouzas Maneiro	2	2				LL	E Guerrero Álvarez	5	5
	LL	E Guerrero Álvarez	6	6																			M Buzărnescu	6	6
	8	F Jones	6	6																		9	A Bolsova	4	2
	Q	N Bains	3	1				8	F Jones	78	6
	JE	D Parry	3	3					D Papamichail	66	1
		D Papamichail	6	6											8	F Jones	64	1
	Q	M Gutiérrez Carrasco	6	0	6										9	A Bolsova	77	6
		Ç Büyükakçay	2	6	4			Q	M Gutiérrez Carrasco	77	4	0
	Q	F Kozaki	2	2				9	A Bolsova	65	6	6
	9	A Bolsova	6	6

References

• Main Draw