The acetoacetyl-CoA synthetase (AACS) gene encodes a protein of the same name, which converts acetoacetate to acetoacetyl-CoA, and plays a crucial role in ketone body utilization and fatty acid synthesis. The gene is found on human chromosome 12.
The AACS protein is a member of the acetyl-CoA synthetase family and is involved in cellular energy production, ketogenesis, and cholesterol synthesis.[5] It is expressed in a wide range of human tissues.[6]
Function
The protein's function is regulated transcriptionally by sterol regulatory element-binding protein (SREBP) and peroxisome proliferator-activated receptor gamma (PPARγ).[7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000081760 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029482 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Q86V21 · AACS_HUMAN". www.uniprot.org. Uniprot. Retrieved 2023-12-09.
- ↑ "AACS acetoacetyl-CoA synthetase". www.ncbi.nlm.nih.gov. NCBI Gene. Retrieved 2023-12-09.
- ↑ Aguiló, Francesca; Camarero, Nuria; Relat, Joana; Marrero, Pedro; Haro, Diego (2010-03-29). "Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARγ" (PDF). Biochemical Journal. 427 (2): 255–264. doi:10.1042/bj20090851. ISSN 0264-6021.
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