CDC26

CDC26
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HYM, 4UI9, 5A31, 5G05, 5G04,%%s4UI9, 5A31
Identifiers
Aliases	CDC26, ANAPC12, APC12, C9orf17, cell division cycle 26
External IDs	OMIM: 614533 MGI: 1913690 HomoloGene: 16410 GeneCards: CDC26
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,275,572 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,326,879 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; monocyte; ; islet of Langerhans; ; lymph node; ; left ventricle; ; rectum; ; right lung; ; endometrium; ; left coronary artery; ; kidney;
	Top expressed in
	medial ganglionic eminence; ; yolk sac; ; abdominal wall; ; endocardial cushion; ; maxillary prominence; ; dermis; ; thymus; ; otic placode; ; intercostal muscle; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; anaphase-promoting complex; nucleus; nucleoplasm;
Biological process	regulation of mitotic metaphase/anaphase transition; cell cycle; anaphase-promoting complex-dependent catabolic process; protein ubiquitination; protein K11-linked ubiquitination; cell division; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	246184
	66440
	ENSG00000176386
	ENSMUSG00000066149
	Q8NHZ8
	Q99JP4
	NM_139286
	NM_139291; NM_001368241
	NP_644815; NP_644815.1
	NP_647452; NP_001355170
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle 26 is a protein that in humans is encoded by the CDC26 gene.^[5]

Function

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008].

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Anaphase-promoting complex subunit CDC26

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176386 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066149 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Cell division cycle 26". Retrieved 2018-10-16.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000176386 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066149 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Cell division cycle 26". Retrieved 2018-10-16.

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