ORMDL1

ORMDL1
Identifiers
Aliases	ORMDL1, ORMDL sphingolipid biosynthesis regulator 1
External IDs	OMIM: 610073 MGI: 2181669 HomoloGene: 41135 GeneCards: ORMDL1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	189,784,364 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	53,349,468 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; spleen; ; monocyte; ; anterior pituitary; ; gastric mucosa; ; right lung; ; gallbladder; ; right uterine tube; ; appendix; ; rectum;
	Top expressed in
	medial ganglionic eminence; ; endocardial cushion; ; abdominal wall; ; left lobe of liver; ; Paneth cell; ; primitive streak; ; atrioventricular valve; ; hair follicle; ; vas deferens; ; epithelium of stomach;
	More reference expression data
	n/a
Orthologs
	94101
	227102
	ENSG00000128699
	ENSMUSG00000026097
	Q9P0S3
	Q921I0
	NM_001128150; NM_016467
	NM_145517
NP_001121622; NP_057551; NP_001358313; NP_001358314; NP_001358315;
	NP_001358316; NP_001358317
	NP_663492
	Wikidata
View/Edit Human	View/Edit Mouse

ORMDL sphingolipid biosynthesis regulator 1 is a protein that in humans is encoded by the ORMDL1 gene. ^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128699 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026097 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: ORMDL sphingolipid biosynthesis regulator 1". Retrieved 2018-01-09.

Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T (2008). "A family of membrane proteins associated with presenilin expression and gamma-secretase function". FASEB J. 22 (3): 819–27. doi:10.1096/fj.07-9072com. PMID 17928364. S2CID 3855661.
Siow DL, Wattenberg BW (2012). "Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis". J. Biol. Chem. 287 (48): 40198–204. doi:10.1074/jbc.C112.404012. PMC 3504734. PMID 23066021.
Gupta SD, Gable K, Alexaki A, Chandris P, Proia RL, Dunn TM, Harmon JM (2015). "Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells". J. Biol. Chem. 290 (1): 90–8. doi:10.1074/jbc.M114.588236. PMC 4281770. PMID 25395622.

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